女性口腔扁平苔藓患者与抑郁的相关性

[收稿日期] 2010-08-20；[修回日期] 20-4-2
[作者简介] 吴晓虹（974）,女,学士,医师,E-mail:qywuxiaohong@http://wendang.chazidian.com
[通信作者] 何旭东,Tel:578-22532,E-mail:mentalsky@http://wendang.chazidian.com
c 211 年版权归《上海口腔医学》编辑部所有
［文章编号］1006-7248(2011)05-0548-05
女性口腔扁平苔藓患者与抑郁的相关性研究
吴晓虹
1
，何旭东
2
，吴松红
3
，夏花
3
1.浙江省温州医学院附属第六医院，丽水市人民医院 口腔科，浙江 丽水 323；
2.浙江省丽水市第二人民医院 老年病防治中心，浙江 丽水 323；
3.浙江省丽水市第二人民医院 精神科，浙江 丽水 323）
[摘要] 目的：探讨女性口腔扁平苔藓(OLP)与抑郁以及血清性激素、皮质醇水平之间的相关性。 方法：将 67 例在口腔
科门诊就诊的女性 OLP 患者按病情分为糜烂组25 例）和非糜烂组42 例），并将在同时期就诊的非口腔黏膜病变的
其他良性口腔疾病设为对照组3 例）采用焦虑自评量表(SAS)抑郁自评量表SDS、汉密尔顿焦虑量表 (HAMA、汉
密尔顿抑郁量表（HAMD、生活事件量表LES进行焦虑、抑郁状况评定,并按 DSMIV 诊断标准筛查抑郁症患者；同
时测量清晨空腹血清性腺激素FSH、LH、E2、T、PRL和皮质醇(CORT，并将结果按月经同期或绝经期分别进行比
较 采用 SPSS 软件包对数据进行卡方、t 检验及 Spearman 秩相关分析 结果：糜烂组病例中， 例4%符合
DSMIV 抑郁症诊断，非糜烂组和对照组则各有 6 例4.3%和  例3.3%符合 糜烂组和非糜烂组的 SAS、SDS、
HAMA、HAMD 分值和 CORT 水平高于对照组P<.5)，但糜烂组和非糜烂组间无显著性差异 糜烂组 LES 分值高于
非糜烂组和对照组，但后两者之间无显著性差异糜烂组和非糜烂组的总生活事件分值及负性生活事件分值与 SAS、
SDS、HAMA、HAMD 分值呈正相关 糜烂组 E2、T 水平低于非糜烂组和对照组P<.5)，非糜烂组亦低于对照组，但无
统计学差异 糜烂组 SDS、HAMD 分值与 E2 和 T 测定值之间均有相关性 P<.5 ) 结论：抑郁在女性糜烂型 OLP 发
生、发展中扮演着重要角色，性激素紊乱可能是其作用机制之一，应激则起到始动作用 对糜烂型 OLP，尤其合并抑
郁的女性患者，适当应用雌激素治疗将有助于病情的缓解
[关键词] 口腔扁平苔藓；抑郁；性激素；皮质醇；女性
[中图分类号] R78.5.9 [文献标志码] A
Study of association between oral lichen planus an epression in female patients WU Xiaohong

, HE Xudong
2
,
WU Song hong
3
, XIA Hua
3
 1.Department of Stomatology, The Sixth Affiliated Hospital of Wenzhou Medical College,
Lishui People’s Hospital. Lishui 323000; 2. Prevention and Treatment Center for Geriatrics, Lishui Second People’s
Hospital. Lishui 323000; 3. Department of Psychiatry, Lishui Second People’s Hospital. Lishui 323000,Zhejiang Province,
China
[Abstract] PURPOSE: To explore the relationship among oral lichen planus (OLP, depression and gonadal hormones in
female patients with OLP METHODS: Sixty seven cases of female out patients with OLP were divided into erosion
group n=25and nonerosion group (n=42 Meanwhile, 3 female outpatients with other benign oral lesion and without
oral mucosa diseases were used as control group Selfrating anxiety scale(SAS, selfrating depression scale(SDS, Hmiton
anxiety scale(HAMA, Hmiton depression scale(HAMD and life event scale(LES were evaluated in all participants who
were tested simultaneously with FSH, LH, E2, T, PRL as well as CORT and were screened with DSMIV criteria for major
depression The data were analyzed by Chisquare test, Student’s t test and Spearman rank correlation using SPSS1
software package RESLS：Ten cases 4%met the DSMIV diagnosis of depression in the erosion group, and 6
(143%, 1 33%in the nonerosion group and control group, respectively The scores of SAS, SDS, HAMA, HAMD and
the level of CORT in both the erosion and nonerosion gro ups were higher than those in the control group,but there was no
significant difference between the erosion group and the nonerosion group The score of LES in the erosion group was
上海口腔医学 2011 年 10 月 第 20 卷 第 5 期
Shanghai Journal of Stomtology Vol．20 No．5 October,2011 548 · ·