人参皂苷Rb1防治脑缺血后神经元损伤的临床价值

脑缺血缺氧时,活化态小胶质细胞介导的炎症反应促进了神经元损伤。因此,寻找能抑制活化的小胶质细胞介导的神经元损伤的药物,是当前防治缺血缺氧性脑病研究领域亟待解决的热点问题之一。由柯荔宁博士所在的中国南方医科大学和福建医科大学研究人员构成的联合研究团队,应用小胶质细胞与神经元共培养,并加入中国传统中药人参皂苷作为药物干预手段。

SICENCE新闻发布 作者：柯荔宁 稿号：N201305029 人参皂苷Rb1防治脑缺血后神经元损伤的临床价值

脑缺血缺氧时，活化态小胶质细胞介导的炎症反应促进了神经元损伤。因此，寻找能抑制活化的小胶质细胞介导的神经元损伤的药物，是当前防治缺血缺氧性脑病研究领域亟待解决的热点问题之

一。由柯荔宁博士所在的中国南方医科大学和福建医科大学研究人员构成的联合研究团队，应用小胶质细胞与神经元共培养，并加入中国传统中药人参皂苷作为药物干预手段。可靠的结果证明人参皂苷Rb1可能通过下调缺氧活化的小胶质细胞中的一氧化氮、O2-、和肿瘤坏死因子α的表达减轻大脑皮质神经元的损伤。这些发现提示人参皂苷Rb1有望成为临床上防治脑缺血后神经元功能退行性变的有效措施，具有潜在的临床应用价值。相关研究发表于《中国神经再生研究（英文版）》杂志2014年2月第3期。

小胶质细胞N9缺氧12h 后，取培养液培养预缺氧12h的神经元，培养12h后，神经元数量明显减少，细胞变形，突起断裂甚至消失，可见大量死亡细胞的碎片、残骸

Article: " Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage," by Lining Ke1, Wei Guo2, Jianwen Xu2, Guodong Zhang1, Wei Wang2, Wenhua Huang1 (1 Department of Human Anatomy, Histology and Embryology,

Southern Medical University, Guangzhou, Guangdong Province, China; 2 Department of Human Anatomy, Histology and Embryology, Fujian Medical University, Fuzhou, Fujian Province, China)

Ke LN, Guo W, Xu JW, Zhang GD, Wang W, Huang WH. Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage. Neural Regen Res. 2014;9(3):252-259.

欲获更多资讯： Neural Regen Res

Clinical value of ginsenoside Rb1 against neuronal damage following cerebral ischemia

Activated microglia-mediated inflammation promotes neuronal damage under cerebral hypoxic-ischemic conditions, so it is likely that inhibiting hypoxia-induced activation of microglia will alleviate neuronal damage. To test this hypothesis, Dr. Lining Ke and co-workers from Southern Medical University and Fujian Medical University in China co-cultured ginsenoside Rb1, an active component of ginseng, and cortical neurons. Their findings indicate that ginsenoside Rb1 attenuates damage to cerebral cortex neurons by downregulation of nitric oxide, superoxide, and tumor necrosis factor-α expression in

脑缺血缺氧时,活化态小胶质细胞介导的炎症反应促进了神经元损伤。因此,寻找能抑制活化的小胶质细胞介导的神经元损伤的药物,是当前防治缺血缺氧性脑病研究领域亟待解决的热点问题之一。由柯荔宁博士所在的中国南方医科大学和福建医科大学研究人员构成的联合研究团队,应用小胶质细胞与神经元共培养,并加入中国传统中药人参皂苷作为药物干预手段。

SICENCE新闻发布 作者：柯荔宁 稿号：N201305029 hypoxia-activated microglia. This study, which has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), suggest that ginsenoside Rb1 is a promising candidate for clinical use in the prevention of neuronal degeneration following cerebral ischemia.

Pre-hypoxic neurons co-cultured in medium from microglia exposed to hypoxia: The number of cultured cells was

significantly lower than in the control group, the residual cells appearing deformed, with fractured or absent processes, and a large amount of debris present from dead cells.

Article: " Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage," by Lining Ke1, Wei Guo2, Jianwen Xu2, Guodong Zhang1, Wei Wang2, Wenhua Huang1 (1 Department of Human Anatomy, Histology and Embryology,

Southern Medical University, Guangzhou, Guangdong Province, China; 2 Department of Human Anatomy, Histology and Embryology, Fujian Medical University, Fuzhou, Fujian Province, China)

Ke LN, Guo W, Xu JW, Zhang GD, Wang W, Huang WH. Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage. Neural Regen Res. 2014;9(3):252-259.