热休克蛋白90可导致多巴胺能神经元死亡并可能揭示帕金森病的运动异常

热休克蛋白90的表达参与帕金森病大鼠神经蛋白的错误折叠及积聚,从而导致多巴胺能神经元死亡。由此,已有研究者认为其可能成为帕金森病治疗的靶点。但其是否与帕金森病后运动障碍,即骨骼肌的运动异常有关尚无证据证实。约旦科技大学医学院Muhammed Al-Jarrah博士所在团队研究发现,耐力训练则可明显抑制帕金森病小鼠腓肠肌和比目鱼肌热休克蛋白90的过表达,从而可能成为缓解帕金森病骨骼肌运动异常的干预标靶。

热休克蛋白90可导致多巴胺能神经元死亡并可能揭示帕金森病的运动异常

热休克蛋白90的表达参与帕金森病大鼠神经蛋白的错误折叠及积聚，从而导致多巴胺能神经元死亡。由此，已有研究者认为其可能成为帕金森病治疗的靶点。但其是否与帕金森病后运动障碍，即骨骼肌的运动异常有关尚无证据证实。约旦科技大学医学院Muhammed Al-Jarrah博士所在团队研究发现，耐力训练则可明显抑制帕金森病小鼠腓肠肌和比目鱼肌热休克蛋白90的过表达，从而可能成为缓解帕金森病骨骼肌运动异常的干预标靶。研究成果发表于《中国神经再生研究（英文版）》杂志2014年3月第6期。

Article: " Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease" by Nour Erekat1, Ahed Al-Khatib2, Muhammed Al-Jarrah3 (1 Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan; 2 Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3 Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan (Current address: Fatima College of Health Sciences (FCHS). Abu Dhabi, UAE)

Erekat N, Al-Khatib A, Al-Jarrah M. Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease. Neural Regen Res. 2014;9(6):616-621.

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HSP90 is a potential target for ameliorating skeletal muscle abnormalities in PD

Heat shock protein (HSP90) has been suggested to be involved in neuronal protein misfolding and accumulation in

Parkinson’s disease (PD) brains leading to dopaminergic neuronal death and the eventual dopamine depletion. Therefore, HSP90 has been suggested as a therapeutic target in PD. Dr. Muhammed Al-Jarrah and co-workers from Jordan University of Science and Technology (JUST) point out exercise training significantly inhibited HSP90 overexpression in the soleus and gastrocnemius in PDe rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in PD. The relevant article has been published in the Neural Regeneration Research (Vol. 9, No. 6, 2014).

Article: " Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease" by Nour Erekat1, Ahed Al-Khatib2, Muhammed Al-Jarrah3 (1 Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan; 2 Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3 Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan (Current address: Fatima College of Health Sciences (FCHS). Abu Dhabi, UAE)

热休克蛋白90的表达参与帕金森病大鼠神经蛋白的错误折叠及积聚,从而导致多巴胺能神经元死亡。由此,已有研究者认为其可能成为帕金森病治疗的靶点。但其是否与帕金森病后运动障碍,即骨骼肌的运动异常有关尚无证据证实。约旦科技大学医学院Muhammed Al-Jarrah博士所在团队研究发现,耐力训练则可明显抑制帕金森病小鼠腓肠肌和比目鱼肌热休克蛋白90的过表达,从而可能成为缓解帕金森病骨骼肌运动异常的干预标靶。

Erekat N, Al-Khatib A, Al-Jarrah M. Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease. Neural Regen Res. 2014;9(6):616-621.