当归多糖可以减轻神经元的氧化损伤

来自中国的传统中药当归已被确切认为具有抗氧化和神经保护作用,但这一作用是否为主要成分当归多糖发挥的呢？中国武汉大学中南医院雷涛博士所在团队的研究,希望证实当归多糖预培养能够：(1)减轻神经元免受氧化应激导致的细胞毒性和细胞凋亡。(2)能够提高脑缺血大鼠大脑皮质神经元的抗氧化损伤能力,增加脑缺血大鼠微血管数量,改善脑血流。

SICENCE新闻发布 作者：雷涛 稿号：N201306015 当归多糖可以减轻神经元的氧化损伤

来自中国的传统中药当归已被确切认为具有抗氧化和神经保护作用，但这一作用是否为主要成分当归多糖发挥的呢？中国武汉大学中南医院雷涛博士所在团队的研究，希望证实当归多糖预培养能够：(1)减轻神经元免受氧化应激导致的细胞毒性和细胞凋亡。(2)能够提高脑缺血大鼠大脑皮质神经元的抗氧化损伤能力，增加脑缺血大鼠微血管数量，改善脑血流。实验结果证实当归多糖具有这些作用，未来在治疗缺血性脑卒中神经元保护性治疗中可发挥更大的潜力。相关文献发表于《中国神经再生研究（英文版）》杂志2014年2月第3期。

激光扫描共聚焦显微镜下，局灶性脑缺血大鼠经当归多糖治疗后，脑组织中灌注微血管密度和分布明显增加

Article: " Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress," by Tao Lei1, Haifeng Li2, Zhen Fang1, Junbin Lin1, Shanshan Wang1, Lingyun Xiao2, Fan Yang2, Xin Liu2, Junjian Zhang1, Zebo Huang2, Weijing Liao1 (1 Department of Rehabilitation Medicine, Zhongnan Hospital and Cerebral Vascular Diseases Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China; 2 School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei Province, China)

Lei T, Li HF, Fang Z, Lin JB, Wang SS, Xiao LY, Yang F, Liu X, Zhang JJ, Huang ZB, Liao WJ. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress. Neural Regen Res. 2014;9(3):260-267.

欲获更多资讯： Neural Regen Res.

Polysaccharides from Angelica sinensis alleviate oxidative damage to neurons

According to traditional Chinese medicine, the roles of Angelica sinensis correlate with tonifying the blood and promoting its circulation. Recent studies have shown that extracts of Angelica sinensis have antioxidative and neuroprotective effects.

来自中国的传统中药当归已被确切认为具有抗氧化和神经保护作用,但这一作用是否为主要成分当归多糖发挥的呢？中国武汉大学中南医院雷涛博士所在团队的研究,希望证实当归多糖预培养能够：(1)减轻神经元免受氧化应激导致的细胞毒性和细胞凋亡。(2)能够提高脑缺血大鼠大脑皮质神经元的抗氧化损伤能力,增加脑缺血大鼠微血管数量,改善脑血流。

SICENCE新闻发布 作者：雷涛 稿号：N201306015 However, the anti-oxidative function of Angelica sinensis polysaccharide has rarely been addressed. In a preliminary experiment from Dr. Tao Lei and colleagues from Zhongnan Hospital of Wuhan University in China, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment. In a rat model of local cerebral ischemia, they further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Their findings, published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.

Under a laser scanning confocal microscopy, perfused microvessels were abundant after treatment with Angelica sinensis polysaccharide.

Article: " Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress," by Tao Lei1, Haifeng Li2, Zhen Fang1, Junbin Lin1, Shanshan Wang1, Lingyun Xiao2, Fan Yang2, Xin Liu2, Junjian Zhang1, Zebo Huang2, Weijing Liao1 (1 Department of Rehabilitation Medicine, Zhongnan Hospital and Cerebral Vascular Diseases Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China; 2 School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei Province, China)

Lei T, Li HF, Fang Z, Lin JB, Wang SS, Xiao LY, Yang F, Liu X, Zhang JJ, Huang ZB, Liao WJ. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress. Neural Regen Res. 2014;9(3):260-267.