中药舒肝解郁胶囊能增加抑郁大鼠脑内神经营养因子的表达

舒肝解郁胶囊于2008年已被中国食药监局批准进入临床治疗,显示对轻中度抑郁具有明显治疗效果。中国中南大学湘雅二医院赵靖平教授领导的团队从营养缺陷可导致抑郁症的假说着手,重点阐述舒肝解郁胶囊对抑郁模型大鼠内侧前额皮质和海马CA3区脑源性神经营养因子和磷酸化环磷酸腺苷反应蛋白结合元件的表达。

SICENCE新闻发布 作者：傅锦华 稿号：N201305058 中药舒肝解郁胶囊能增加抑郁大鼠脑内神经营养因子的表达

舒肝解郁胶囊于2008年已被中国食药监局批准进入临床治疗，显示对轻中度抑郁具有明显治疗效果。中国中南大学湘雅二医院赵靖平教授领导的团队从营养缺陷可导致抑郁症的假说着手，重点阐述舒肝解郁胶囊对抑郁模型大鼠内侧前额皮质和海马CA3区脑源性神经营养因子和磷酸化环磷酸腺苷反应蛋白结合元件的表达。结果发现舒肝解郁胶囊能够显著上调大鼠脑内脑源性神经营养因子和磷酸化环磷酸腺苷反应蛋白结合元件的表达，这可能是舒肝解郁胶囊抗抑郁作用的机制之一。相关文献发表于《中国神经再生研究（英文版）》杂志2014年3月第5期。

免疫组化染色显示，经150 mg/kg舒肝解郁胶囊治疗的抑郁模型大鼠内侧前额皮质中脑源性神经营养因子表达增加

Article: " Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression," by Jinhua Fu1, 2, Yingjin Zhang3, Renrong Wu1, Yingjun Zheng4, Xianghui Zhang1, Mei Yang2, Jingping Zhao1, Yong Liu1 (1 Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, China; 2 Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan Province, China; 3 Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 4 Guangzhou Brain Hospital, Affliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong Province, China)

Fu JH, Zhang YJ, Wu RR, Zheng YJ, Zhang XH, Yang M, Zhao JP, Liu Y. Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression. Neural Regen Res. 2014;9(5):489-497

欲获更多资讯： Neural Regen Res

Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression

Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. Prof. Jingping Zhao and team

舒肝解郁胶囊于2008年已被中国食药监局批准进入临床治疗,显示对轻中度抑郁具有明显治疗效果。中国中南大学湘雅二医院赵靖平教授领导的团队从营养缺陷可导致抑郁症的假说着手,重点阐述舒肝解郁胶囊对抑郁模型大鼠内侧前额皮质和海马CA3区脑源性神经营养因子和磷酸化环磷酸腺苷反应蛋白结合元件的表达。

SICENCE新闻发布 作者：傅锦华 稿号：N201305058 from the Second Xiangya Hospital, Central South University in China conducted a study to examine the effect of

Shuganjieyu capsule on behavioral changes in a rat model of depression. They focused on the underlying mechanisms of Shuganjieyu capsule by examining brain-derived neurotrophic factor and phosphorylated cyclic adenosine monophosphate response element binding protein expression levels in the medial prefrontal cortex and hippocampal CA3 area. The results presented in this study demonstrate that Shuganjieyu capsule effectively reverses depressive-like behaviors by increasing brain-derived neurotrophic factor and phosphorylated cyclic adenosine monophosphate response element binding protein expression levels in the medial prefrontal cortex and hippocampalCA3 area of depressive-like rats, which may be one of the anti-depressant mechanisms of Shuganjieyu capsule. This study has been published in the Neural Regeneration Research (Vol. 9, No. 5, 2014).

150 mg/kg Shuganjieyu capsule significantly increased brain-derived neurotrophic factor expression in the medial prefrontal cortex of rats with depressive-like behaviors (immunohistochemical staining).

Article: " Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression," by Jinhua Fu1, 2, Yingjin Zhang3, Renrong Wu1, Yingjun Zheng4, Xianghui Zhang1, Mei Yang2, Jingping Zhao1, Yong Liu1 (1 Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, China; 2 Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan Province, China; 3 Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 4 Guangzhou Brain Hospital, Affliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong Province, China)

Fu JH, Zhang YJ, Wu RR, Zheng YJ, Zhang XH, Yang M, Zhao JP, Liu Y. Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression. Neural Regen Res. 2014;9(5):489-497