Synthesis of polylactic acid by direct polycondensation under vacuum without catalysts聚乳酸直接缩聚
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Synthesis of polylactic acid by direct polycondensation under vacuum without catalysts聚乳酸直接缩聚
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ChemicalEngineeringJournal151(2009)342–350
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Synthesisofpolylacticacidbydirectpolycondensationundervacuumwithoutcatalysts,solventsandinitiators
FeerzetAchmad,KenjiYamane,ShiQuan,TakaoKokugan?
DepartmentofChemicalEngineering,TokyoUniversityofAgricultureandTechnology,2-24-16Naka-cho,Koganei-shi,Tokyo184-8588,Japan
articleinfoabstract
Inordertoreducetheproductioncostofpolylacticacid(PLA),l-lacticacidwaspolymerizedbydirectpolycondensation(DP)undervacuumwithoutcatalysts,solventsandinitiators.Experimentswerecon-ductedatpolymerizationtemperatures(Tp)of150–250?C.ThemaximumPLAmolecularweightobtainedwas90kDaat200?Cafter89hundervacuum.Above200?C,PLAisthermallydegradedbyspeci?cscis-sion.TheDPactivationenergy(Ea)wasalsoinvestigatedandwasfoundtobelargerthanthatrequiredbycatalyzedringopeningpolymerization(ROP).Furthermore,theEawashigherthanthedeactivationenergy(Ed)forbothDPandROP.PLAyieldswerehigheratlowerTp,whiletheyieldoflactideincreasedwithTp.ThetotalyieldofPLAandlactidewasapproximately52–75wt.%.TheuncatalyzedDPmethodmayhaveapplicationsinon-sitecellplantproduction,wherecompactnessisrequired,aswellassafeandsimpleoperatingprocedures.
©2009ElsevierB.V.Allrightsreserved.
Articlehistory:
Received27November2008
Receivedinrevisedform2April2009Accepted3April2009Keywords:
Polylacticacid
DirectpolycondensationOn-sitecellplant
1.Introduction
Recently,thedemandforplasticsmadefrombiomass(bio-plastics)hasincreasedbecausetheycanreduceenvironmentalcarbondioxideemissions,whichinducesglobalwarming,andtheirproductiondoesnotrequirefossilfuelresources,thusreducingtheenvironmentalloadrequiredtoproducetheseplastics.Ifbio-plasticsaregoingtobeabletoaddresstheissuesofglobalwarmingorfossilfueluse,theywillneedtobeusedinlargequantities.However,theuseofbio-plasticsremainslimitedbecausetheirpro-ductioncostsare3–10timeshigherthanthoseofconventionalplastics[1].
Polylacticacid(PLA)derivedfrombiomassisatypicalbio-plasticthatcanbemadeinathree-stepprocessoffermentation,separationandpolymerization.NatureWorksCo.(USA)hasproducedPLAfromrecombinantcornbymeansofanintensivelarge-scaleprocessthatreducesproductioncosts[2].
InanattempttofurtherreducethecostofproducingPLA,weproposedanon-sitecellplantmethodforallthreeprocesses.Forthefermentationprocess,l-lacticacidwasfermentedusingfreshcassavaroot(FCR)asthesubstrateandconcentrateofmagurowaste(CMW)andtofuliquidwaste(TLW)asthemedium,withoutsac-chari?cationandStreptococcusbovisasthebacterialstrain[1,3,4].ThepolymerizationprocessusedtosynthesizePLAwasdirectpoly-condensation(DP)undervacuumwithoutcatalysts,solventsand
initiators.Thisprocessful?llstheconditionsofcompactness,aswellassafeandsimpleoperationforanon-sitecellplantconcept.PLAistypicallysynthesizedbyringopeningpolymerization(ROP)oflactide,aprocessthatusescatalystssuchastin,zinc,alu-minumandlead,initiatorssuchasn-,sec-andtert-butyllithium,andsolventssuchasdiphenylether,tolueneandchloroform.Manyofthesecomponentsaretoxicor?ammable.Asaresult,thispro-cessrequirespuri?cationtoremovetheunwantedmaterialsfromtheproduct,whichrequirescomplexfacilities[5,6].
ThispaperreportsthesynthesisofPLAbyDPwithoutcatalysts,solventsandinitiatorsbyvaryingtheTpfrom150to250?Candthepressurefromatmospherepressuretovacuumfor96h,inaccor-dancewiththespeci?cationsforon-sitecellplants.ThepropertiesofthePLAsynthesizedbyDPwerecomparedwiththoseofPLAsynthesizedbyROP.2.Materialsandmethods2.1.Materials
l-Lacticacid(l-LA:specialgrade)wassuppliedbyWakoPureChemicalIndustries,Ltd.(Tokyo,Japan)withamonomerconcentra-tionof60wt.%,atotalacidityof90wt.%andadensityof1.224kg/L.Chloroform(WakoPureChemicalIndustries,Ltd.(Tokyo,Japan))wasusedastheeluentingelpermeationchromatography(GPC).ThepolystyrenestandardforGPCcalibrationandthelactidestan-dardforFTIRanalysesweresuppliedbySigma–AldrichChemicalCo.(USA).WeusedPLAproducedbyLeceaMitsuiChemicalsInc.(Japan)asastandard.
?Correspondingauthor.Tel.:+81423887062;fax:+81423887062.E-mailaddress:kokugant@cc.tuat.ac.jp(T.Kokugan).1385-8947/$–seefrontmatter©2009ElsevierB.V.Allrightsreserved.doi:10.1016/j.cej.2009.04.014
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F.Achmadetal./ChemicalEngineeringJournal151(2009)342–350343
Nomenclature[A]0initialconcentrationofthe–COOHor–OHgroup
[molL?1]
[A]concentrationofthe–COOHgroup[molL?1]
[B]concentrationofcyclicmonomerB,e.g.,lactide[molL?1]
[B]0initialconcentrationofcyclicmonomerB[molL?1][Cat]catalystconcentration[molL?1]
Eaactivationenergyofpolymerization[kJmol?1]
Eddeactivationenergyofthermaldegradation[kJmol?1]
k1?rstorderrateconstantforROPpolymerizationsoflactide[min?1]
k?1
?rstorderrateconstantforthermaldegradationinROPpolymerizationsoflactide[min?1]
kRappapparentrateconstantofpolymerizationforROP[Lmol?1min?1]
kR?app
apparentrateconstantofthermaldegradationforROP[min?1]
k2
secondorderrateconstantofpolymerizationforDP[Lmol?1min?1]
kD2
app
apparentpolymerizationrateconstantforDP[min?1]
kD2
?app
apparentrateconstantofthermaldegradationforDP[min?1]
k3thirdorderrateconstantofpolymerizationforDP[L2mol?2min?2]
Mnnumberaveragemolecularweight[g/mol]Mwweightaveragemolecularweight[g/mol]
ndegreeofpolymerizationinstepwisepolymeriza-tion
Pdegreepolymerizationinringopeningpolymeriza-tion
tTime[min]
TTemperature[?C],[K]
ωinitialmonomerconcentrationofl-LA[wt.%]??
Density[kg/L]
2.2.Apparatusandprocedures
Fig.1showstheexperimentalapparatususedforpolymer-izations.Polymerizationswereconductedina1Lfour-neckedseparable?askequippedwithamechanicalstirrerandare?uxcondenserconnectedtoaninlinecoldtrapandavacuumpump.Thermocoupleswereusedtomeasuretheinternalandexteriortemperaturesofthesolutioninthereactorandtheexteriorofthe?ask.Tocontroltheinternalandexteriortemperaturesofthereac-tor,mainandsub-heaterswereinstalledsurroundingthereactor.Thereactorpressurewasmeasuredbyatransducerandmonitoredbyacomputer.Thepressureinthereactorwasloweredincremen-tallyusingavacuumpump.
Twohundredgramsofl-LAwasaddedtothe?ask,andPLAwassynthesizedbydirectpolycondensation(DP)throughthreeoperations:distillation,oligomerizationandpolymerization.Thetemperatureandpressureduringthepolymerizationwerepre-ciselycontrolled.
First,duringthedistillationperiod,l-LAwasheatedtothedistil-lationtemperature(Td)of150?C,afterwhichthetemperaturewasmaintainedattheTdfor150minatatmospherepressure.Thiswasfollowedbytheoligomerizationperiod,whichlastedbetween150and300min.Thetemperatureandpressurewerethenbroughttothepolymerizationtemperature(Tp)andvacuum,respectively.The
pressurewasreducedincrementallyto10mmHgover?ve30minperiods.Thedistillatewasremovedfromthecondensertrapandmeasuredevery30min.Then,duringthepolymerizationperiod,thel-LAwaspolymerizedatvariouspolymerizationtemperatures(Tp)between150and250?Cat10mmHgfor96h.Samplesweretakenfromthereactorandthetrapat12hintervals.Attheendofthereaction,theproductswerepouredintoaPetridishandallowedtocooltoroomtemperature.2.3.Analyticalmethod
Theconcentrationsofthel-LAmonomerinthereactorandtrapwereanalyzedbyabiosensorequippedwithanautosam-pler(BF-5:OjiScienti?cInstruments,Osaka).Thetotalacidityinthel-LAsolutionwasanalyzedtodeterminetheoligomerconcen-tration,ascalculatedbyanacid–basetitrationmethod(JISK8726).Theamountofoligomerpresentwascalculatedfromthediffer-encebetweentheamountofmonomerandthetotalacidity.ThePLA’sweightaveragemolecularweight(Mw),numberaveragemolecularweight(Mn)andMw/Mnratioweredeterminedusingagelpermeationchromatography(GPC)systemequippedwithtwochromatographycolumns(ShodexK803andShodexK804)andaRIdetector.Chloroformwasusedastheeluentata?owrateof1mL/min,andthemolecularweightswerecalibratedtoapolystyrenestandardat40?C.ThefunctionalgroupsofPLA,lactideandl-LAwereanalyzedbyFourierTransformInfraredSpectroscopy(FTIR:JASCOFT/IR-4100ST).3.Basicconsiderations
3.1.Therateofstepwisepolymerization
a.Self-catalyzedpolymerization
Intheabsenceofanexogenousstrongacid,theacidmonomeractsasitsowncatalystintheesteri?cationreaction.Thecon-densationcanbeexpectedtobethirdorderoverallintheconcentrationofthe–OHand–COOH(orA)functionalgroups[7,8]:d[A]
dt
=?k3·[?OH]·[A]2,(1)
wherek3istherateconstantofthethirdorderreaction,and[–OH]and[A]aretheconcentrationsof–OHandAgroups,respectively.
Sincethereisone–OHgroupforeach–COOHgroup,theequa-tioncanbewrittenas:d[A]
dt
=?k3·[A]3.(2)
IntegrationofEq.(2)yields:[A]20[A]
2
?1=2[A]20·k3·t.
(3)
However,thedegreeofpolymerization(n)inastepwisepoly-merizationcanbeexpressedbyEq.(4)(assumingnomassislost):n=
[A]0
[A]
.(4)
Thus,Eq.(3)canbesimpli?edto:n2?1=2[A]20·k3·t.
(5)
Eq.(5)makesclearthattherelationshipbetween(n2?1)andtshouldbelinearifthepolymerizationfollowsthismodelofself-catalyzedpolymerization.
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Fig.1.TheexperimentalapparatusforPLApolymerization.(1)Four-neckedseparable?ask,(2)main-heater,(3)thermocouple,(4)sub-heater,(5)condensatetrap,(6)condenser,(7)coldtrap,(8)controlvalve,(9)vacuumpump,(10)stirrer,(11)pressuregauge,(12)transducer,(13)ampli?er,(14)A/Dconverter,(15)temperatureindicatingcontroller(TIC),and(16)personalcomputer.
b.Externalcatalysisofpolymerization
Thestepwisepolymerizationinvolvinganexternalcatalystfol-lowsthesecondorderreaction[7,8]:d[A]
=?k2·[?OH]·[A],dt
(6)
Ontheotherhand,thecoef?cientk1isproportionaltothecon-centrationofthecatalystinROP,thatis:
R
k1=kapp·[Cat],
(14)
wherek2istherateconstantofthesecondorderreaction.Setting
[–OH]=[A]gives:d[A]
=?k2·[A]2.dt
IntegrationofEq.(7)gives:[A]0
?1=[A]0·k2·t.[A]
CombiningEq.(4)andEq.(8)yields:n?1=[A]0·k2·t.
(9)(8)(7)
RwherekappistheapparentrateconstantofpolymerizationforROP
and[Cat]isthecatalystconcentration.
Insertingthecoef?cientk1intoEq.(12)yields:
d[B]R
=?kapp·[B][Cat].dt
(15)
3.3.Therateofthepolymer’sthermaldegradationbythecatalystTherateofthepolymer’sthermaldegradationinthepresenceofacatalystisgivenbyEq.(16)[12]:dP
=?k?1·P,dt
(16)
Eq.(9)showsthattherelationshipbetween(n?1)andtshouldbelinearifthepolymerizationfollowsthismodelofexternalcatalysis.Wede?netheapparentpolymerizationrateconstantDk2asshowninEq.(10):
app
wherek?1istherateconstantforthermaldegradationandPisthe
degreeofpolymerization.
Thecoef?cientk?1isproportionaltothecatalystconcentration,thatis:
R
k?1=k?app·[Cat],
(17)
D
k2=k2·[A]0.app
(10)
SubstitutingEq.(10)intoEq.(9)yields:
Dn?1=k2·t.app
(11)
Rwherek?appistheapparentrateconstantofthermaldegradation
bythecatalyst.
Insertingthecoef?cientk?1intoEq.(16)yieldsEq.(18):
3.2.Therateofringopeningpolymerization
Theringopeningpolymerization(ROP)reactionisa?rstorderreaction[9–11],thus:d[B]
=?k1·[B],dt
(12)
dPR
=?k?app·P·[Cat].dt
(18)
Thus,therateofthethermaldegradationreactioninthepres-enceofacatalystisthesameastherateofROPpolymerization.4.Resultsanddiscussion
4.1.Impactoftemperatureandpressureontotalcondensateduringthedistillationandoligomerizationperiods
Fig.2showsthetemperatureandpressureinthereactor(a)andthetotalcondensateremoved(b)atvariouspolymerizationtemperatures(Tp)andpressuresover300mininthedistillationandoligomerizationperiods.Atabout45min,asecondorderphasetransitionoccurredat128±2?Cinthereactant(pointPinFig.2a),
where[B]istheconcentrationofcyclicmonomerandk1isthe?rstorderrateconstantforthereaction.WeobtainEq.(13)byintegrat-ingEq.(12):ln
[B]0
=k1·t,[B]
(13)
where[B]0istheinitialconcentrationofcyclicmonomerB.
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Thecondensateonthewallsofthe?askandinthecondenserwaspreliminarilymeasuredtoweigh6.0g.Duringtheoligomerizationperiod(150min<t<300min),thetotalcondensateincreasedasaresultoftheincrementalreductioninpressure.Duringthepolymer-izationperiod,thetemperatureandpressurewerekeptconstantatTpand10mmHgfrom300minto96h.
4.2.Therateofpolymerizationandthermaldegradation
Fig.3showstheeffectofpolymerizationtime(t)onthedegreeofpolymerizationofthepolylacticacid(n)atvariouspolymerizationtemperatures(Tp)between150and250?C.Fortheself-catalyzedpolymerizationwiththirdorderkinetics,therelationshipbetween(n2?1)andtisshowninFig.3a,whiletheplotofthesec-ondorderreactionusinganexternalcatalystisshowninFig.3b.Theexperimentalresultssupportthemodelofanexternallycat-alyzedpolymerization,since(n?1)andthavealinearrelationship(Fig.3b)fromEq.(11).Thatis,thereactionmechanismforl-LApolymerizationbyuncatalyzedDP,isoverallsecondorder,becausel-LAisastrongacidthatactsasacatalystduringpolymerization,inspiteofthelargeamountofmasslostundertheseconditions.
DTheratecoef?cientk2inEq.(11)wasobtainedfromtheslope
app
Fig.2.Thetemperatureandpressureinthereactor(a)andtotalcondensateremoved
(b)duringthedistillationandoligomerizationperiods.Atfollowingpolymerizationtemperature150?C(??),170?C(??),180?C(??),190?C(?),200?C(??),210?C(?),220?C(??),230?C(??),250?C(*).
whereheatwasconstantlysupplieduntil150?Cwasreachedandthetotalacidityofthel-LAincreasedtoabout100wt.%from90wt.%bydistillation.Theamountsofwater,monomerandoligomerinthereactorandcondensatewereinagreementwiththediagrambyVickroy[13].Atabout90min,thereactortemperaturereachedthespeci?eddistillationtemperatureTdof150?C,whichwasmain-tainedthroughoutthedistillationperioduntil150minhadelapsed.Thetemperatureandpressureconditionsthroughoutthedistilla-tionperiodwerethesameforalltrials.
Thetotalcondensatewasmeasuredasthecondensateinthetrapandthecondensateadheringtothewallsofthe?askandcondenser.
ofthegraphinFig.3b,whilethecoef?cientk2wascalculatedfromEq.(10).
WealsocomparedthepolymerizationrateconstantforDPwiththatofringopeningpolymerization(ROP).Thepolymerizationrate
RisanforROPisrepresentedbyEq.(15),andthecoef?cientkapp
apparentsecondorderreactionrateconstant,inwhichthetermsthatappearintheratelawaretheconcentrationsoflactideand
Rcatalyst.Thepolymerizationrateconstantsk2andkapphavethe
?1?1samedimension[Lmolmin].
AtTp=200?C,thedegreeofPLApolymerization(n)reached1260at89handdecreasedafterthatpoint.Athightemperatures,PLAisinequilibriumwithradicallactidebyradicalhomolysispathways[14].Sincethemeltingpointoflactideis94–96?C,lactideisvapor-izedathightemperaturesandlowpressures,andisthentrappedbythecondenser.Asthermaldegradationtakesplaceandlactideisdistilled,PLAshiftstoalowermolecularweight.PLA’sequilibriumwithradicallactidedependsonthetemperature.Thermaldegrada-tionwasfoundtooccurat200?Cwhennocatalystispresent.Highertemperaturesleadtofasterandmoreprevalentthermaldegrada-tion.Forexample,atTp=250?C,thedegreeofpolymerizationisabout509after10h.Theboundarywherepolymerizationand
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Fig.3.Theeffectofpolymerizationtime(t)onthedegreeofPLApolymerization(n).Symbols:150?C(??),170?C(??),180?C(??),190?C(?),200?C(??),210?C(?),220?C(??),230?C(??),250?C(*).
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Fig.4.TheeffectsofpolymerizationtemperatureonthePLA’smolecularweightandMw/Mn.Symbols:Mw(??),Mn(??),ratioMw/Mn(??);atTp≤200?Cfort=89h,atTp>200?Cfort=maximummolecularweight.
maldegradationoccursimultaneouslyisshownbythedashedlineinFig.3b.
Thisstudyevaluatedtherateofthermaldegradationbyrep-resentingtheexperimentalreactionrateconstant(kD2?app
)fortheuncatalyzedthermaldegradationas:
n?1=kD
2
?app
·t+b.(19)
However,OkamotoandMatsuo[12]studiedthecatalyzedther-maldegradationofPLAandproposedtheratelawshowninEq.(16).Thecoef?cientk?1isthe?rstorderrateconstantforthermaldegradationinthepresenceofacatalyst.Thethermaldegradation
rateconstantskD2?app
andk?1havethesamedimensions[min?1].Fig.4showstheeffectsofpolymerizationtemperature(Tp)on
theweightaveragemolecularweight(Mw),thenumberaveragemolecularweight(Mn)andthePLA’sMw/Mnratio.ForTp<200?C,MwandMnarethemolecularweightsatt=89h,thetimewhenthePLAreacheditsmaximummolecularweight(90kDa)atTp=200?C(inFig.3b)andforTp>200?C,theMwandMnparametersarethemaximumvaluesallowedbythermaldegradation.
Harseetal.[15]studiedthesynthesisofPLAfroml-LAbyDPandfoundthatthePLAreachedamaximumMwof7kDausingSnCl2asthecatalystandaMwof2.35kDawithoutacatalystat180?Cafter24hundernitrogenatmosphere.Kaitianetal.[16]reportedamaximumMwof6kDaford,l-PLAsynthesizedbyuncatalyzedandsolvent-freeDPat200?Cfor24hundernitrogenatmosphere.LowMwpolymersresultedduetodif?cultiesinremovingwaterfromthebulkpolymerization.Ajiokaetal.[17]havereportedthepolymerizationofl-LAbyDPusingaSncatalystanddiphenyletherasthesolvent.HighMWPLA(240kDa)wasproducedafter24hat130?C.Inthepresenceofacatalystandsolvent,thesmallamountofwaterremaininginthereactionmixturecanberemovedazeotrop-icallyatarelativelylowtemperatureunderhighvacuum.However,suchaprocessrequiresmultiplereactors,complexfacilitiesandapuri?cationsteptoremovethecatalystandthesolventfromtheproduct[6].
CommerciallyavailablePLA,suchasthatproducedbyNatureWorks,issynthesizedfromlactidebyROPusingatinoctoatecatalystat180–210?Cfor5h.TheMwofthePLAproducedis111–145kDa[http://wendang.chazidian.comingthesamemethod,Ajiokaetal.[17]reportedthepolymerizationofl-LactidebyROPusingtinoctoateasthecatalystand1-dodecanolasthesolvent.ThisprocedureproducedhighMWPLA(430kDa)after5hat200?C.WhiletheMwofPLAobtainedbyourpresentconditionsislowerthanthat
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Fig.5.Arrheniusplotforthepolymerizationandthermaldegradationofpolylacticacid.Symbols:Polymerization(??),andthermaldegradation(?)bypresentwork,Kaitian(),Eguiburu(),Tang(??),polymerization()andthermaldegradation(??)byOkamoto,HarsheusedTi(BuO)4(??)andSnCl2()ascatalysts,Ra?er().
byROP,ourpolymerizationconditionsaresuitableforon-siteproduction.
TheuncatalyzedpolycondensationprocessdidnotgiveahigherPLAmolecularweight.Becausethedehydrativepolycondensationofl-LAisdrivenbyself-catalysisfroml-LA’scarboxylgroup,theprogressofthecondensationdecreasesasthetotalamountofcar-boxylgroupinsituisreducedbythepolycondensationreaction[7,19].AnotherreasonforthegenerationoflowMwpolymersisthatthepolycondensationprocessiscarriedoutatmoderatetohightemperaturesandunderastrongvacuum,whichnotonlyallowsforafastreactionrate,butalsoaidsintheremovalofasmallamountofthereactants[7].
TheMw/MnratioforPLAproducedinuncatalyzedDPreac-tionsvariesfrom2.0to3.2.Ontheotherhand,thisratiois1.5–3.77forPLAproducedbyROP[10,20,21],1.4–5.5forcatalyzedDP[6,15,16,19,22,23]and2.16–2.65foruncatalyzedDPusingd,l-lacticacid[15,16].TheratioforDPwaslargerthanthatobtainedbyROP,aprocesswithahigherpolymerizationrateandalowerpolymerizationtemperaturethanthoseinthepresentstudy.ThebroadrangeintheMw/Mnratiooccurredbecauseofintramolec-ulartrans-esteri?cationofthepolymerchainsthatresultedintheformationoflactideandlowMwpolymers[16,22,24].Thesephe-nomenawerecausedbyhigherpolymerizationtemperaturesandlongerpolymerizationtimes.
4.3.Activationanddeactivationenergiesforthepolymerizationofpolylacticacid
Wecomparedtheactivationenergy(Ea)ofpolymerizationandthedeactivationenergy(Ed)ofthermaldegradationfortheDPmethodwiththoseoftheROPmethod.Fig.5showstheArrheniusplotforpolymerizationsandthermaldegradationsunderdirectpolycondensationandringopeningpolymerizationconditions.The
polymerizationrateconstantsk2andkRappwerecalculatedfromEq.
(10)fortheDPmethod(presentstudy)andfromEq.(14)fortheROPmethod,respectively.
[A]0inEq.(4)iscalculatedusingEq.(20):[A]ω×??0=
(20)
whereωisthemonomerconcentration,??isthedensity,andMistheinitialmolecularweightofl-LA.Propagationconstantsareplottedagainstthelefthandy-axisassolidlinesinFig.5.However,
thethermaldegradationrateconstantskD2?app
andk?1werecalcu-
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