针刺外关穴促进了脑卒中患者感觉相关脑区神经元的激活

有研究发现发现针刺缺血性脑卒中患者外关穴(SJ5)与针刺其非穴比较,在与躯体运动(Brodmann area 4,6,8)、躯体感觉(Brodmann area 7,39,40)、视觉及听觉(Brodmann area 18,19,22)、精神情志(Brodmann area 13,24,32,28)等有关的脑区神经元存在激活/负激活差异,但具体哪种脑区在针刺外关穴治疗脑卒中过程中起决定性作用尚不明确。

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作者：祁冀 稿号：N201303076 针刺外关穴促进了脑卒中患者感觉相关脑区神经元的激活

有研究发现发现针刺缺血性脑卒中患者外关穴(SJ5)与针刺其非穴比较，在与躯体运动(Brodmann area 4，6，8)、躯体感觉(Brodmann area 7，39，40)、视觉及听觉(Brodmann area 18，19，22)、精神情志(Brodmann area 13，24，32，28)等有关的脑区神经元存在激活/负激活差异，但具体哪种脑区在针刺外关穴治疗脑卒中过程中起决定性作用尚不明确。目前能够追踪到的经穴特异性的研究，大部分是探讨生理状态下针刺对患者脑功能的影响的差异，而病理状态下的研究较少见。中国南方医科大学中医药学院祁冀等所在课题组进行的一项研究，比较了16例针刺缺血脑卒中患者外关穴和非穴对脑部功能区神经元激活/负激活效应的差异。结果发现，针刺脑组织患者针刺外关穴可显著激活感觉相关的体感联合皮质(Brodmann area 5)脑功能区神经元。作者认为，感觉相关的体感联合皮质(Brodmann area 5)脑功能区神经元的特异性变化可能与外关穴治疗缺血性脑卒中的中枢机制相关，这为针刺治疗脑卒中提供了参考依据。文章发表在《中国神经再生研究（英文版）》杂志2014年2月第3期。

功能磁共振检测发现，脑卒中患者进行非穴针刺治疗后，左脑BA10有负激活点（蓝色）。

Article: " Acupuncture at Waiguan and sham points influences activation of functional brain areas of ischemic stroke patients: a functional magnetic resonance imaging study" by Ji Qi1, Junqi Chen2, Yong Huang1, Xinsheng Lai3, Chunzhi Tang3, Junjun Yang4, Hua Chen5, Shanshan Qu1 (1 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China; 2 Department of Rehabilitation, The Third Affiliated Hospital of

Southern Medical University, Guangzhou, Guangdong Province, China; 3 School of Acupuncture-moxibustion and Tuina, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China; 4 School of Chinese Medicine, Hongkong Baptist University, Hongkong, China; 5 School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong Province, China) Qi J, Chen JQ, Huang Y, Lai XS, Tang CZ, Yang JJ, Chen H, Qu SS. Acupuncture at Waiguan and sham points influences activation of functional brain areas of ischemic stroke patients: a functional magnetic resonance imaging study. Neural Regen Res. 2014;9(3):293-300.

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有研究发现发现针刺缺血性脑卒中患者外关穴(SJ5)与针刺其非穴比较,在与躯体运动(Brodmann area 4,6,8)、躯体感觉(Brodmann area 7,39,40)、视觉及听觉(Brodmann area 18,19,22)、精神情志(Brodmann area 13,24,32,28)等有关的脑区神经元存在激活/负激活差异,但具体哪种脑区在针刺外关穴治疗脑卒中过程中起决定性作用尚不明确。

SICENCE新闻发布 作者：祁冀 稿号：N201303076

Acupuncture at Waiguan improves activation of functional brain areas of stroke patients

Both acupuncture at Waiguan (SJ5) and sham acupuncture can activate/deactivate several brain regions in patients with ischemic stroke, but there are some difference in Brodmann areas 4, 6, 8, Brodmann areas 7, 39, 40, Brodmann areas 18, 19, 22 and Brodmann areas 13, 24, 32, 28. Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. Dr. Ji Qi and co-workers from School of Traditional Chinese Medicine, Southern Medical University in China examined the effects of acupuncture on brain function in a pathological context, and compared the effects between Waiguan and sham points in 16 patients with ischemic stroke. Compared with sham acupuncture, acupuncture at Waiguan in stroke patients inhibited Brodmann area 5 on the healthy side. These findings, published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), indicated that the altered specificity of sensation-associated cortex (Brodmann area 5) is possibly associated with a central mechanism of acupuncture at Waiguan for stroke patients.

Decreased activity was observed in left Brodmann area 10 during sham acupuncture. Blue represents inhibition.

Article: " Acupuncture at Waiguan and sham points influences activation of functional brain areas of ischemic stroke patients: a functional magnetic resonance imaging study" by Ji Qi1, Junqi Chen2, Yong Huang1, Xinsheng Lai3, Chunzhi Tang3, Junjun Yang4, Hua Chen5, Shanshan Qu1 (1 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China; 2 Department of Rehabilitation, The Third Affiliated Hospital of

Southern Medical University, Guangzhou, Guangdong Province, China; 3 School of Acupuncture-moxibustion and Tuina, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China; 4 School of Chinese Medicine, Hongkong Baptist University, Hongkong, China; 5 School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong Province, China) Qi J, Chen JQ, Huang Y, Lai XS, Tang CZ, Yang JJ, Chen H, Qu SS. Acupuncture at Waiguan and sham points influences activation of functional brain areas of ischemic stroke patients: a functional magnetic resonance imaging study. Neural Regen Res. 2014;9(3):293-300.