功能性电刺激可促进脑梗死后的神经元再生

神经系统损伤后,有时会出现神经前体细胞再生的现象,但目前研究表明内源性的神经前体细胞增殖程度难以代偿神经元和轴突的受损。中国中山大学向云博士所在课题组进行了一项研究,直接观察功能性电刺激对脑卒中急性期大鼠肢体运动功能恢复的作用,同时检测功能性电刺激对大鼠缺血侧与正常侧海马齿状回和室管膜下区内源性神经前体细胞的影响和碱性成纤维细胞生长因子、表皮生长因子含量变化。

SICENCE新闻发布 作者：向云 稿号：N201304014 功能性电刺激可促进脑梗死后的神经元再生

神经系统损伤后，有时会出现神经前体细胞再生的现象，但目前研究表明内源性的神经前体细胞增殖程度难以代偿神经元和轴突的受损。中国中山大学向云博士所在课题组进行了一项研究，直接观察功能性电刺激对脑卒中急性期大鼠肢体运动功能恢复的作用，同时检测功能性电刺激对大鼠缺血侧与正常侧海马齿状回和室管膜下区内源性神经前体细胞的影响和碱性成纤维细胞生长因子、表皮生长因子含量变化。结果发现，功能性电刺激能促进急性脑梗死大鼠脑部内源性神经前体细胞的增殖、碱性成纤维细胞生长因子及表皮生长因子的表达，并改善大鼠运动功能。实验结果可为临床更好地应用功能性电刺激奠定了重要的理论基础。文章发表在《中国神经再生研究（英文版）》杂志2014年2月第3期。

免疫组织化学染色显示，功能性电刺激增加脑卒中大鼠脑部颗粒细胞层的巢蛋白阳性细胞（箭头）数量

Article: " Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction" by Yun Xiang1, 2, Huihua Liu1, Tiebin Yan1, Zhiqiang Zhuang1, Dongmei Jin1, Yuan Peng3 (1 Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 2 Department of Rehabilitation Medicine, Shenzhen Sixth People’s Hospital, Shenzhen, Guangdong Province, China; 3 Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou, Guangdong Province, China)

Xiang Y, Liu HH, Yan TB, Zhuang ZQ, Jin DM, Peng Y. Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction. Neural Regen Res. 2014;9(3):243-251.

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神经系统损伤后,有时会出现神经前体细胞再生的现象,但目前研究表明内源性的神经前体细胞增殖程度难以代偿神经元和轴突的受损。中国中山大学向云博士所在课题组进行了一项研究,直接观察功能性电刺激对脑卒中急性期大鼠肢体运动功能恢复的作用,同时检测功能性电刺激对大鼠缺血侧与正常侧海马齿状回和室管膜下区内源性神经前体细胞的影响和碱性成纤维细胞生长因子、表皮生长因子含量变化。

SICENCE新闻发布 作者：向云 稿号：N201304014

Functional electrical stimulation improves neuronal regeneration after cerebral infarction

Previous studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. From the perspective of neural plasticity, Dr. Yun Xiang and co-workers from Sun Yat-sen University in China observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. The researchers found that functional electrical stimulation can promote endogenous neural precursor cell proliferation in the brains of acute cerebral infarction rats, enhance expression of basic fibroblast growth factor and epidermal growth factor, and improve the motor function of rats. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).

Functional electrical stimulation increased the number of nestin-positive cells (arrows) in the subgranular zone of stroke rats.

Article: " Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction" by Yun Xiang1, 2, Huihua Liu1, Tiebin Yan1, Zhiqiang Zhuang1, Dongmei Jin1, Yuan Peng3 (1 Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 2 Department of Rehabilitation Medicine, Shenzhen Sixth People’s Hospital, Shenzhen, Guangdong Province, China; 3 Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou, Guangdong Province, China)

Xiang Y, Liu HH, Yan TB, Zhuang ZQ, Jin DM, Peng Y. Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the

brains of rats with cerebral infarction. Neural Regen Res. 2014;9(3):243-251.