腰背痛时各脑区间的功能连接变换

脑默认网络作为静息状态下重要的网络,包括后扣带回、楔前叶、前额叶中部和颞叶内侧皮质,维持各脑区正激活与负激活平衡,是大脑结构连接和功能连接的关键节点。一项在健康志愿者制作成腰背痛模型的研究报告说,人体大脑在静息状态下,腰背痛受试者默认网络与岛叶的功能连接存在异常。

SICENCE新闻发布 作者： 张珊珊 稿号：NRR_17_14 腰背痛时各脑区间的功能连接变换

脑默认网络作为静息状态下重要的网络，包括后扣带回、楔前叶、前额叶中部和颞叶内侧皮质，维持各脑区正激活与负激活平衡，是大脑结构连接和功能连接的关键节点。一项在健康志愿者制作成腰背痛模型的研究报告说，人体大脑在静息状态下，腰背痛受试者默认网络与岛叶的功能连接存在异常。静息态功能连接研究的是静息状态时各脑区之间的低频涨落信号波动的相关性，近年来凭借其无创性及可明确脑区之间连接性等特点，成为研究人脑功能活动的有效工具，但目前针对腰背痛静息态的功能连接研究较少，尤其是各个脑区之间的功能联系机制尚不明确。中国南方医科大学珠江医院张珊珊等所课题组发现，正常人在腰背痛状态下脑默认网络的功能连接存在异常，岛叶与前额叶中部、颞叶内侧皮质连接增高，与后扣带回、楔前叶、顶下小叶连接减低。此外，前扣带回与前后岛叶的功能连接结果不同，与后岛叶显示功能连接增强，与前岛叶的功能连接减低。作者认为，疼痛时广泛的皮质及皮质下区域功能连接受损，可能与疼痛刺激引起一系列认知与情绪功能的改变有关。文章发表在《中国神经再生研究（英文版）》杂志2014年1月第2期。

腰背痛受试者静息状态下疼痛时各感兴趣区(mPFC, PCC, LTC, aIC and pIC)正、负（A,B）功能连接变化图(P ＜ 0.001，K≥10，未校正) 彩色区域显示疼痛状态与正常时相比有差异的脑区。mPFC：前额叶中部；PCC：后扣带回；LTC：颞叶内侧；aIC ：前岛叶；pIC：后岛叶

Article: " Resting-state connectivity in the default mode network and insula during experimental low back pain," by Shanshan Zhang1, Wen Wu1, Guozhi Huang1, Ziping Liu1, Shigui Guo1, Jianming Yang2, Kangling Wang1 (1 Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China; 2 Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China)

Zhang SS, Wu W, Huang GZ, Liu ZP, Guo SG, Yang JM, Wang KL. Resting-state connectivity in the default mode network and insula during experimental low back pain. Neural Regen Res. 2014;9(2):135-142.

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脑默认网络作为静息状态下重要的网络,包括后扣带回、楔前叶、前额叶中部和颞叶内侧皮质,维持各脑区正激活与负激活平衡,是大脑结构连接和功能连接的关键节点。一项在健康志愿者制作成腰背痛模型的研究报告说,人体大脑在静息状态下,腰背痛受试者默认网络与岛叶的功能连接存在异常。

SICENCE新闻发布 作者： 张珊珊 稿号：NRR_17_14 Resting-state functional connectivity during experimental low back pain

The default mode network is a key area in the resting state, involving the posterior cingulate cortex, precuneus, medial prefrontal and lateral temporal cortices, and is characterized by balanced positive and negative connections classified as the “hubs” of structural and functional connectivity in brain studies. Resting-state functional connectivity MRI is based on the observation that brain regions exhibit correlated slow fluctuations at rest, and has become a widely used tool for

investigating spontaneous brain activity. Functional magnetic resonance imaging studies have shown that the insular cortex has a significant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the default mode network and insula during pain remain unclear. Shanshan Zhang and co-workers from Zhujiang Hospital, Southern Medical University in China compared the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline in healthy subjects. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the importance of the interaction between these regions in pain processing. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 2, 2014).

Resting-state functional connectivity map showing positively (A) and negatively (B) correlated voxels for seed regions of interest (mPFC, PCC, LTC, aIC and pIC) in low back pain subjects (P < 0.001, K ≥ 10, uncorrected). Color area: Regions with differences between pain state and normal. mPFC: Medial prefrontal cortex; PCC: posterior cingulate cortex; LTC: lateral temporal cortex; aIC: anterior insula; pIC: posterior insula.

Article: " Resting-state connectivity in the default mode network and insula during experimental low back pain," by Shanshan Zhang1, Wen Wu1, Guozhi Huang1, Ziping Liu1, Shigui Guo1, Jianming Yang2, Kangling Wang1 (1 Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China; 2 Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China)

Zhang SS, Wu W, Huang GZ, Liu ZP, Guo SG, Yang JM, Wang KL. Resting-state connectivity in the default mode network and insula during experimental low back pain. Neural Regen Res. 2014;9(2):135-142.