你在用阿托伐他汀治疗脑缺血再灌注损伤吗？

许多研究显示,他汀类药物除了降脂作用外,尚有抗炎、抗氧自由基等多种独立于其降脂作用的效果,他汀类药物产生的心肌组织保护作用大于其单纯降脂作用。他汀类药物能对缺血再灌注损伤中产生保护作用已得到多数人认可,但其具体机制尚不明确,在脑缺血再灌注损伤中的研究更少。

SICENCE新闻发布 作者：涂秋云 稿号：N201302003 你在用阿托伐他汀治疗脑缺血再灌注损伤吗？

许多研究显示，他汀类药物除了降脂作用外，尚有抗炎、抗氧自由基等多种独立于其降脂作用的效果，他汀类药物产生的心肌组织保护作用大于其单纯降脂作用。他汀类药物能对缺血再灌注损伤中产生保护作用已得到多数人认可，但其具体机制尚不明确，在脑缺血再灌注损伤中的研究更少。中南大学湘雅三医院涂秋云博士所在课题组进行的一项研究证实，阿托伐他汀通过抗炎及抗氧化的途径减轻脑缺血再灌注损伤。作者以此推测他汀类药物可能为脑血管疾病患者的治疗带来益处。研究结果发表在《中国神经再生研究（英文版）》杂志2014年2月第3期上。

免疫组织化学染色显示，阿托伐他汀预处理的脑缺血再灌注损伤大鼠缺血皮质区域的E-选择素（箭头）表达明显增加（×400）

Article: " Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects " by Qiuyun Tu1, Hui Cao2, Wei Zhong 2, Binrong Ding1, Xiangqi Tang1 (1 Departments of Geriatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 2 Departments of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China)

Tu QY, Cao H, Zhong W, Ding BR, Tang XQ. Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. Neural Regen Res. 2014;9(3):268-275.

欲获更多资讯： Neural Regen Res

Atorvastatin protects against cerebral ischemia/reperfusion injury

In addition to its lipid-lowering effect, statins exert anti-inflammatory and antioxidant effects as well. Statins also provide protection against renal, pulmonary and myocardial ischemia/reperfusion injury. However, little evidence is available on similar changes in cerebral ischemia/reperfusion injury. Therefore, Dr. Qiuyun Tu and colleagues from Third Xiangya Hospital of Central South University in China verified that atorvastatin, a commonly used lipid-lowering drug, protects

许多研究显示,他汀类药物除了降脂作用外,尚有抗炎、抗氧自由基等多种独立于其降脂作用的效果,他汀类药物产生的心肌组织保护作用大于其单纯降脂作用。他汀类药物能对缺血再灌注损伤中产生保护作用已得到多数人认可,但其具体机制尚不明确,在脑缺血再灌注损伤中的研究更少。

SICENCE新闻发布 作者：涂秋云 稿号：N201302003 against cerebral ischemia/reperfusion injury through anti-infammatory and antioxidant effects. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).

ischemia/reperfusion (× 400). Atorvastatin pretreatment significantly increased E-selectin (arrow) expression in the cortex of rats with cerebral

Article: " Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects " by Qiuyun Tu1, Hui Cao2, Wei Zhong 2, Binrong Ding1, Xiangqi Tang1 (1 Departments of Geriatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 2 Departments of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China)

Tu QY, Cao H, Zhong W, Ding BR, Tang XQ. Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. Neural Regen Res. 2014;9(3):268-275.