非霍奇金淋巴瘤NHL综述
上传者:戴右铭|上传时间:2017-06-04|密次下载
非霍奇金淋巴瘤NHL综述
Seminar
Non-Hodgkin lymphoma
James O Armitage, Randy D Gascoyne, Matthew A Lunning, Franco Cavalli
Lymphomas can a? ect any organ in the body, present with a wide range of symptoms, and be seen by primary care physicians and physicians from most specialties. They are traditionally divided into Hodgkin’s lymphoma (which accounts for about 10% of all lymphomas) and non-Hodgkin lymphoma, which is the topic of this Seminar. Non-Hodgkin lymphoma represents a wide spectrum of illnesses that vary from the most indolent to the most aggressive malignancies. They arise from lymphocytes that are at various stages of development, and the characteristics of the speci? c lymphoma subtype re? ect those of the cell from which they originated. Since this topic was last reviewed in The Lancet in 2012, advances in understanding the biology and genetics of non-Hodgkin lymphoma and the availability of new diagnostic methods and therapies have improved our ability to manage patients with this disorder.
Published OnlineJanuary 30, 2017
http://www.wendangwang.com/10.1016/S0140-6736(16)32407-2
Epidemiology and risk factors
Since the last review of non-Hodgkin lymphoma in The Lancet in 2012,1 advances in understanding the biology and genetics and the availability of new diagnostic methods and therapies have improved. An estimated 72 580 new cases of non-Hodgkin lymphoma are expected in the USA in 2016, and 13 413 new cases were reported in the UK in 2013.2,3 The relative frequency of speci? c subtypes of non-Hodgkin lymphoma varies geographically. The International Non-Hodgkin Lymphoma Classi? cation
4
Project studied 4539 cases from seven geographical regions (North America, western Europe, southeastern Europe, Central and South America, north Africa and Middle East, southern Africa, and the east Asia). Non-Hodgkin lymphomas were more likely to be B-cell lymphomas, and there was a higher incidence of low-grade B-cell lymphomas in high-income regions than in low-income and middle-income regions. By contrast, low-income and middle-income regions had a higher incidence of high-grade B-cell lymphomas and T-cell and natural killer (NK)-cell lymphomas than did high-income regions. Nasal-type extranodal NK–T-cell lymphoma was much more common in the east Asia—and, to a lesser degree, in Central and South America—than in other regions. Extranodal NK–T-cell lymphoma is strongly associated with Epstein-Barr virus infection, but the striking geographical variability in the incidence of this subtype of lymphoma indicates a contribution of host susceptibility. However, one study5 found that the distribution of lymphoma subtypes in Japan was changing and becoming more like the distribution found in the USA (ie, it was becoming westernised), suggesting that changes in lifestyle can alter these patterns.
Trends in the incidence of non-Hodgkin lymphoma have not been consistent. The incidence of non-Hodgkin lymphoma in Europe and North America increased in the 1990s and then stablised.6,7 However, looking at overall trends of incidence might not re? ect changes in the incidence of speci? c subtypes. For example, a study8 from the Netherlands that focused on the period from 1989 to 2007 showed that the incidence of indolent B-cell lymphomas, and T-cell and NK-cell non-Hodgkin lymphomas, rose considerably whereas the incidence of aggressive B-cell lymphomas remained stable.
occupational factors.9–11 Obesity has been found to be a Correspondence to: risk factor for di? use large B-cell lymphoma (DLBCL).12 Prof James O Armitage,
Genome-wide association studies have found loci that University of Nebraska Medical are associated with excessive risk for follicular lymphoma, Center, Nebraska Medical Center,
Omaha, NE 68198-7680, USA
marginal zone lymphoma, and DLBCL.13,14 joarmita@unmc.eduThe e? ects of some key risk factors such as hair dyes seem to be decreasing owing to changes in the ingredients used in these products.15 The risk of non-Hodgkin lymphoma in patients with autoimmune diseases—including rheumatoid arthritis, Sjgren syndrome, and systemic lupus erythematosus—has continued to increase.16 Whether this increased risk is related only to the autoimmune disease or to the immunosuppressive therapies used in its management is not clear. Patients who are immunosuppressed for other reasons, such as patients undergoing organ transplantation or those with HIV infection, are known to be at an increased risk of developing non-Hodgkin lymphoma.17
Both viral and bacterial infections have been closely associated with the development of non-Hodgkin lymphomas. Helicobacter pylori causes most gastric mucosa-associated lymphoid tissue (MALT) lymphomas.18 The Epstein-Barr virus is closely associated with both Burkitt lymphoma and nasal NK–T-cell lymphoma.19,20 Hepatitis C virus has been associated with splenic marginal zone lymphoma and DLBCL.21 Borrelia burgdorferi and Chlamydia psittacosis are thought to be
Search strategy and selection criteria
We searched PubMed and MEDLINE for articles published in English between Jan 1, 2012, and April 1, 2016, using the terms “non-Hodgkin lymphoma”, “di? use large B-cell
lymphoma”, “follicular lymphoma”, “mantle cell lymphoma”, “marginal zone lymphoma”, “Burkitt lymphoma”, “T-cell lymphoma” and “peripheral T-cell lymphoma”. In some cases, these manuscripts provided further references that were not included in the original search results but were included in this manuscript.
University of Nebraska Medical Center, Omaha, NE, USA (Prof J O Armitage MD, M A Lunning DO); British Columbia Cancer Agency and British Columbia Cancer Research Centre, Vancouver,
Factors a? ecting an individual’s risk of developing non-BC, Canada
Hodgkin lymphoma have been extensively studied. (Prof R D Gascoyne MD); and These factors include immune disorders, medicines, Oncology Institute of Southern
Switzerland, Bellinzona,
infections, lifestyle, genetics, race, family history, and Switzerland (Prof F Cavalli MD)
http://www.wendangwang.com Published online January 30, 2017 http://www.wendangwang.com/10.1016/S0140-6736(16)32407-2 1
下载文档
热门试卷
- 2016年四川省内江市中考化学试卷
- 广西钦州市高新区2017届高三11月月考政治试卷
- 浙江省湖州市2016-2017学年高一上学期期中考试政治试卷
- 浙江省湖州市2016-2017学年高二上学期期中考试政治试卷
- 辽宁省铁岭市协作体2017届高三上学期第三次联考政治试卷
- 广西钦州市钦州港区2016-2017学年高二11月月考政治试卷
- 广西钦州市钦州港区2017届高三11月月考政治试卷
- 广西钦州市钦州港区2016-2017学年高一11月月考政治试卷
- 广西钦州市高新区2016-2017学年高二11月月考政治试卷
- 广西钦州市高新区2016-2017学年高一11月月考政治试卷
- 山东省滨州市三校2017届第一学期阶段测试初三英语试题
- 四川省成都七中2017届高三一诊模拟考试文科综合试卷
- 2017届普通高等学校招生全国统一考试模拟试题(附答案)
- 重庆市永川中学高2017级上期12月月考语文试题
- 江西宜春三中2017届高三第一学期第二次月考文科综合试题
- 内蒙古赤峰二中2017届高三上学期第三次月考英语试题
- 2017年六年级(上)数学期末考试卷
- 2017人教版小学英语三年级上期末笔试题
- 江苏省常州西藏民族中学2016-2017学年九年级思想品德第一学期第二次阶段测试试卷
- 重庆市九龙坡区七校2016-2017学年上期八年级素质测查(二)语文学科试题卷
- 江苏省无锡市钱桥中学2016年12月八年级语文阶段性测试卷
- 江苏省无锡市钱桥中学2016-2017学年七年级英语12月阶段检测试卷
- 山东省邹城市第八中学2016-2017学年八年级12月物理第4章试题(无答案)
- 【人教版】河北省2015-2016学年度九年级上期末语文试题卷(附答案)
- 四川省简阳市阳安中学2016年12月高二月考英语试卷
- 四川省成都龙泉中学高三上学期2016年12月月考试题文科综合能力测试
- 安徽省滁州中学2016—2017学年度第一学期12月月考高三英语试卷
- 山东省武城县第二中学2016.12高一年级上学期第二次月考历史试题(必修一第四、五单元)
- 福建省四地六校联考2016-2017学年上学期第三次月考高三化学试卷
- 甘肃省武威第二十三中学2016—2017学年度八年级第一学期12月月考生物试卷
网友关注
- 总复习 雨具的改进答案
- 第一章 第三节 月球和地月系Word
- 【中华古籍】国学经典-二十四赋品
- 吸收式热泵Word
- 2015年修订版马克思主义基本原理概论第二章第二节真理与价值Word
- 歌颂青春.Word
- 十八届六中全会精神学习党课课件Word
- 第一讲 中国体制改革与经济发展Word
- TSG T7001-2009宣贯Word
- 26个英文字母的书写笔划顺序-四线三格Word
- 任务5 MOST总线系统检测与修复Word
- 母亲节Word
- 【中华古籍】国学启蒙经典-家常语
- 历史意识与史学意识的深化1Word
- 第四章 公司法Word
- 第三章:政策理念、政策主体、政策环境与政策工具Word
- 电子商务概论1Word
- 中国传统节日Word
- 燃气发电机组基本构造与工作原理Word
- 第十章:政策终结Word
- 【中华古籍】国学经典-梁溪词
- 04-加强施工过程控制Word
- 党积极分子结课课件 梁嘉欣Word
- 现浇混凝土空心板QC演讲Word
- 语法一 概述 判断句Word
- 【中华古籍】国学启蒙经典-龙文鞭影
- 桥基工程岩体力学研究Word
- 诗歌常见典故歌诀
- 常用的表面处理介绍Word
- 2014英语(重庆卷)精校打印版含答案
网友关注视频
- 冀教版小学数学二年级下册第二单元《有余数除法的简单应用》
- 冀教版小学英语四年级下册Lesson2授课视频
- 冀教版英语三年级下册第二课
- 化学九年级下册全册同步 人教版 第25集 生活中常见的盐(二)
- 【部编】人教版语文七年级下册《泊秦淮》优质课教学视频+PPT课件+教案,广东省
- 沪教版八年级下册数学练习册21.3(3)分式方程P17
- 【部编】人教版语文七年级下册《老山界》优质课教学视频+PPT课件+教案,安徽省
- 人教版历史八年级下册第一课《中华人民共和国成立》
- 北师大版八年级物理下册 第六章 常见的光学仪器(二)探究凸透镜成像的规律
- 北师大版小学数学四年级下册第15课小数乘小数一
- 【部编】人教版语文七年级下册《逢入京使》优质课教学视频+PPT课件+教案,辽宁省
- 外研版英语三起5年级下册(14版)Module3 Unit1
- 沪教版八年级下册数学练习册20.4(2)一次函数的应用2P8
- 【部编】人教版语文七年级下册《泊秦淮》优质课教学视频+PPT课件+教案,湖北省
- 二年级下册数学第三课 搭一搭⚖⚖
- 每天日常投篮练习第一天森哥打卡上脚 Nike PG 2 如何调整运球跳投手感?
- 外研版英语七年级下册module3 unit1第二课时
- 冀教版小学数学二年级下册第二周第2课时《我们的测量》宝丰街小学庞志荣.mp4
- 第五单元 民族艺术的瑰宝_15. 多姿多彩的民族服饰_第二课时(市一等奖)(岭南版六年级上册)_T129830
- 七年级英语下册 上海牛津版 Unit3
- 《空中课堂》二年级下册 数学第一单元第1课时
- 苏科版数学 八年级下册 第八章第二节 可能性的大小
- 沪教版牛津小学英语(深圳用) 五年级下册 Unit 7
- 《小学数学二年级下册》第二单元测试题讲解
- 飞翔英语—冀教版(三起)英语三年级下册Lesson 2 Cats and Dogs
- 第五单元 民族艺术的瑰宝_16. 形形色色的民族乐器_第一课时(岭南版六年级上册)_T1406126
- 第19课 我喜欢的鸟_第一课时(二等奖)(人美杨永善版二年级下册)_T644386
- 【部编】人教版语文七年级下册《老山界》优质课教学视频+PPT课件+教案,安徽省
- 第8课 对称剪纸_第一课时(二等奖)(沪书画版二年级上册)_T3784187
- 河南省名校课堂七年级下册英语第一课(2020年2月10日)
精品推荐
- 2016-2017学年高一语文人教版必修一+模块学业水平检测试题(含答案)
- 广西钦州市高新区2017届高三11月月考政治试卷
- 浙江省湖州市2016-2017学年高一上学期期中考试政治试卷
- 浙江省湖州市2016-2017学年高二上学期期中考试政治试卷
- 辽宁省铁岭市协作体2017届高三上学期第三次联考政治试卷
- 广西钦州市钦州港区2016-2017学年高二11月月考政治试卷
- 广西钦州市钦州港区2017届高三11月月考政治试卷
- 广西钦州市钦州港区2016-2017学年高一11月月考政治试卷
- 广西钦州市高新区2016-2017学年高二11月月考政治试卷
- 广西钦州市高新区2016-2017学年高一11月月考政治试卷
分类导航
- 互联网
- 电脑基础知识
- 计算机软件及应用
- 计算机硬件及网络
- 计算机应用/办公自动化
- .NET
- 数据结构与算法
- Java
- SEO
- C/C++资料
- linux/Unix相关
- 手机开发
- UML理论/建模
- 并行计算/云计算
- 嵌入式开发
- windows相关
- 软件工程
- 管理信息系统
- 开发文档
- 图形图像
- 网络与通信
- 网络信息安全
- 电子支付
- Labview
- matlab
- 网络资源
- Python
- Delphi/Perl
- 评测
- Flash/Flex
- CSS/Script
- 计算机原理
- PHP资料
- 数据挖掘与模式识别
- Web服务
- 数据库
- Visual Basic
- 电子商务
- 服务器
- 搜索引擎优化
- 存储
- 架构
- 行业软件
- 人工智能
- 计算机辅助设计
- 多媒体
- 软件测试
- 计算机硬件与维护
- 网站策划/UE
- 网页设计/UI
- 网吧管理